About Protas

Protas is an independent not-for-profit organisation, designing and delivering large, global randomized clinical trials of treatments for common and other life-threatening diseases. Protas is led by the epidemiologist and physician, Professor Sir Martin Landray, who has over 20 years’ experience of leading large, randomized clinical trials as part of a team at Oxford University’s Nuffield Department of Population Health. Most recently, he co-led the landmark RECOVERY clinical trial into treatments for COVID-19 which identified that treatment with the inexpensive steroid drug dexamethasone, improved the chances of survival for the most severe cases. It’s an incredibly rewarding place to work where you’ll be surrounded by supportive colleagues who are experts in their own field of excellence.

About the Role

As Trial Programmer within our Science team, you will transform clinical trial data into a form compliant with standards published by the Clinical Data Interchange Standards Consortium (CDISC). You’ll be responsible for extracting data from Protas’s Unified Clinical Trial Management Platform (Cantata), preparing tabular datasets that comply with CDISC Study Data Tabulation Model (SDTM) standards, and transforming such SDTM data into analysis-ready datasets with CDISC Analysis Data Model (ADaM) standards, ensuring these are fully documented and produced in a timely way for use by statisticians and others.

You’ll also be responsible for the automated production of SDTM-ready data directly from case report forms in collaboration with developers of Cantata. You will be required to provide an expert input into Cantata’s ongoing development, ensuring future automated dataset production is increasingly aligned with SDTM principles.

About you

You have significant programming experience in SAS, C/C++, Python, SQL, R or a similar language, experience of clinical trial IT principles and the design aspects of managing large and complex datasets, experience applying CDISC SDTM, ADaM and Define.xml standards within a clinical trial environment, and preparing and submitting SDTM and ADaM datasets and associated documentation to pharmaceutical companies or regulatory authorities. You are methodical, with well-developed critical thinking skills and rigorous attention to detail as well as a skilled communicator who is able to communicate complex information in simple terms.

Additional Information

Protas is committed to being a diverse and inclusive organisation.

We strongly encourage applications from people from all backgrounds. For disabled applicants, please contact us to let us know of any adjustments we can make to support you during the recruitment process.

We are currently a primarily remote working organisation however there are expectations for travel for attendance at meetings, the frequency of which vary by role and team. We welcome applications from locations across the UK (applicants must have the right to work in the UK)

We are open to discussions on flexible working arrangements. Salary – £57,000 per annum

Closing date for applications – 24th May 2024

Job Description